Yin-Yang! X-Change Alternative

Kaoru Sakurazuka is a normal young man, besides his unusually feminine features. Even his name, Kaoru, is a common name for both girls and boys. His friends don't care, and he enjoys living in a cheap apartment with his buddies Touya and Renji.

One day he feeling strangely ill, so Kaoru visits the school doctor, who is more like a crackpot chemist that enjoying creating new concoctions in the name of science. Upon his visit, Kaoru accidentally drinks a vial marked 'experimental medicine' – and the next day Kaoru, the boy, has become Kaoru, the girl! While he desperately tries to find a way to return to normal, he's forced to spend his days in his new female body.

Kaoru is surprised at the changes in his environment now that he's a girl. Everywhere he goes he's the center of attention, and it seems that everyone takes an interest in him. What strange adventures are in store for Kaoru, now that he has this new body to test-out?