Important: You need to open Pulse audio volume control (pavucontrol) and in the configuration tab disable Rocksmith guitar adapter so the guitar cable gets connected.

For the best latency do the following:

- Change load-module module-udev-detect to load-module module-udev-detect tsched=0 in /etc/pulse/default.pa

https://wiki.archlinux.org/index.php/PulseAudio/Troubleshooting#Glitches.2C_skips_or_crackling

- Open Wine configuration, Audio tab, and instead of system default set your current audio output as your output device